1s78

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[[Image:1s78.jpg|left|200px]]
[[Image:1s78.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1s78 |SIZE=350|CAPTION= <scene name='initialview01'>1s78</scene>, resolution 3.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1s78", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ERBB2, HER2, NGL, NEU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1s78| PDB=1s78 | SCENE= }}
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|RELATEDENTRY=[[1n8y|1N8Y]], [[1n8z|1N8Z]], [[1l7i|1L7I]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s78 OCA], [http://www.ebi.ac.uk/pdbsum/1s78 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s78 RCSB]</span>
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}}
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'''Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex'''
'''Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex'''
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[[Category: Vajdos, F F.]]
[[Category: Vajdos, F F.]]
[[Category: Vos, A M.de.]]
[[Category: Vos, A M.de.]]
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[[Category: cysteine-rich domain]]
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[[Category: Cysteine-rich domain]]
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[[Category: fab fragment]]
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[[Category: Fab fragment]]
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[[Category: leucine-rich repeat]]
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[[Category: Leucine-rich repeat]]
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[[Category: receptor-antibody complex]]
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[[Category: Receptor-antibody complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:23:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:38:24 2008''
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Revision as of 05:23, 3 May 2008

Image:1s78.jpg

Template:STRUCTURE 1s78

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex


Overview

We have determined the 3.2 A X-ray crystal structure of the extracellular domain of the human epidermal growth factor receptor 2 (ErbB2 or HER2) in a complex with the antigen binding fragment of pertuzumab, an anti-ErbB2 monoclonal antibody also known as 2C4 or Omnitarg. Pertuzumab binds to ErbB2 near the center of domain II, sterically blocking a binding pocket necessary for receptor dimerization and signaling. The ErbB2-pertuzumab structure, combined with earlier mutagenesis data, defines the pertuzumab residues essential for ErbB2 interaction. To analyze the ErbB2 side of the interface, we have mutated a number of residues contacting pertuzumab and examined the effects of these mutations on pertuzumab binding and ErbB2-ErbB3 heterodimerization. We have also shown that conserved residues previously shown to be necessary for EGF receptor homodimerization may be dispensible for ErbB2-ErbB3 heterodimerization.

About this Structure

1S78 is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex., Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX, Cancer Cell. 2004 Apr;5(4):317-28. PMID:15093539 Page seeded by OCA on Sat May 3 08:23:04 2008

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