1sox

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1sox" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sox, resolution 1.9&Aring;" /> '''SULFITE OXIDASE FROM ...)
Current revision (09:09, 22 May 2024) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1sox.gif|left|200px]]<br /><applet load="1sox" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1sox, resolution 1.9&Aring;" />
 
-
'''SULFITE OXIDASE FROM CHICKEN LIVER'''<br />
 
-
==Overview==
+
==SULFITE OXIDASE FROM CHICKEN LIVER==
-
The molybdenum-containing enzyme sulfite oxidase catalyzes the conversion, of sulfite to sulfate, the terminal step in the oxidative degradation of, cysteine and methionine. Deficiency of this enzyme in humans usually leads, to major neurological abnormalities and early death. The crystal structure, of chicken liver sulfite oxidase at 1.9 A resolution reveals that each, monomer of the dimeric enzyme consists of three domains. At the active, site, the Mo is penta-coordinated by three sulfur ligands, one oxo group, and one water/hydroxo. A sulfate molecule adjacent to the Mo identifies, the substrate binding pocket. Four variants associated with sulfite, oxidase deficiency have been identified: two mutations are near the, sulfate binding site, while the other mutations occur within the domain, mediating dimerization.
+
<StructureSection load='1sox' size='340' side='right'caption='[[1sox]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1sox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SOX FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sox OCA], [https://pdbe.org/1sox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sox RCSB], [https://www.ebi.ac.uk/pdbsum/1sox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sox ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SUOX_CHICK SUOX_CHICK]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/so/1sox_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sox ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The molybdenum-containing enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Deficiency of this enzyme in humans usually leads to major neurological abnormalities and early death. The crystal structure of chicken liver sulfite oxidase at 1.9 A resolution reveals that each monomer of the dimeric enzyme consists of three domains. At the active site, the Mo is penta-coordinated by three sulfur ligands, one oxo group, and one water/hydroxo. A sulfate molecule adjacent to the Mo identifies the substrate binding pocket. Four variants associated with sulfite oxidase deficiency have been identified: two mutations are near the sulfate binding site, while the other mutations occur within the domain mediating dimerization.
-
==About this Structure==
+
Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase.,Kisker C, Schindelin H, Pacheco A, Wehbi WA, Garrett RM, Rajagopalan KV, Enemark JH, Rees DC Cell. 1997 Dec 26;91(7):973-83. PMID:9428520<ref>PMID:9428520</ref>
-
1SOX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with SO4, MTE, MO, HEM, EPE and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SOX OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase., Kisker C, Schindelin H, Pacheco A, Wehbi WA, Garrett RM, Rajagopalan KV, Enemark JH, Rees DC, Cell. 1997 Dec 26;91(7):973-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9428520 9428520]
+
</div>
-
[[Category: Gallus gallus]]
+
<div class="pdbe-citations 1sox" style="background-color:#fffaf0;"></div>
-
[[Category: Single protein]]
+
-
[[Category: Sulfite oxidase]]
+
-
[[Category: Kisker, C.]]
+
-
[[Category: Rees, D.C.]]
+
-
[[Category: Schindelin, H.]]
+
-
[[Category: EPE]]
+
-
[[Category: GOL]]
+
-
[[Category: HEM]]
+
-
[[Category: MO]]
+
-
[[Category: MTE]]
+
-
[[Category: SO4]]
+
-
[[Category: oxidoreductase]]
+
-
[[Category: sulfite oxidation]]
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:32:06 2007''
+
==See Also==
 +
*[[Sulfite Oxidase|Sulfite Oxidase]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Gallus gallus]]
 +
[[Category: Large Structures]]
 +
[[Category: Kisker C]]
 +
[[Category: Rees DC]]
 +
[[Category: Schindelin H]]

Current revision

SULFITE OXIDASE FROM CHICKEN LIVER

PDB ID 1sox

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sox"
Personal tools