1soy

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{{Seed}}
 
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[[Image:1soy.png|left|200px]]
 
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==Solution structure of the bacterial frataxin orthologue, CyaY==
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The line below this paragraph, containing "STRUCTURE_1soy", creates the "Structure Box" on the page.
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<StructureSection load='1soy' size='340' side='right'caption='[[1soy]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1soy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SOY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1soy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1soy OCA], [https://pdbe.org/1soy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1soy RCSB], [https://www.ebi.ac.uk/pdbsum/1soy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1soy ProSAT]</span></td></tr>
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{{STRUCTURE_1soy| PDB=1soy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYAY_ECOLI CYAY_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/so/1soy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1soy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CyaY is the bacterial ortholog of frataxin, a small mitochondrial iron binding protein thought to be involved in iron sulphur cluster formation. Loss of frataxin function leads to the neurodegenerative disorder Friedreich's ataxia. We have solved the solution structure of CyaY and used the structural information to map iron binding onto the protein surface. Comparison of the behavior of wild-type CyaY with that of a mutant indicates that specific binding with a defined stoichiometry does not require aggregation and that the main binding site, which hosts both Fe(2+) and Fe(3+), occupies a highly anionic surface of the molecule. This function is conserved across species since the corresponding region of human frataxin is also able to bind iron, albeit with weaker affinity. The presence of secondary binding sites on CyaY, but not on frataxin, hints at a possible polymerization mechanism. We suggest mutations that may provide further insights into the frataxin function.
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===Solution structure of the bacterial frataxin orthologue, CyaY===
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Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites.,Nair M, Adinolfi S, Pastore C, Kelly G, Temussi P, Pastore A Structure. 2004 Nov;12(11):2037-48. PMID:15530368<ref>PMID:15530368</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1soy" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15530368}}, adds the Publication Abstract to the page
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*[[Frataxin 3D Structures|Frataxin 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15530368 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_15530368}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1SOY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOY OCA].
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==Reference==
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<ref group="xtra">PMID:15530368</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Adinolfi, S.]]
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[[Category: Large Structures]]
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[[Category: Kelly, G.]]
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[[Category: Adinolfi S]]
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[[Category: Nair, M.]]
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[[Category: Kelly G]]
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[[Category: Pastore, A.]]
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[[Category: Nair M]]
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[[Category: Pastore, C.]]
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[[Category: Pastore A]]
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[[Category: Temussi, P.]]
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[[Category: Pastore C]]
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[[Category: Frataxin]]
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[[Category: Temussi P]]
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[[Category: Friedreich's ataxia iron binding]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:43:57 2009''
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Current revision

Solution structure of the bacterial frataxin orthologue, CyaY

PDB ID 1soy

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