Aldo-keto reductase
From Proteopedia
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*'''AKR1D1''' is responsible for the catalysis of 5-β-reduction of bile acid intermediates and steroid hormones carrying a δ(4)-3-one structure.<br /> | *'''AKR1D1''' is responsible for the catalysis of 5-β-reduction of bile acid intermediates and steroid hormones carrying a δ(4)-3-one structure.<br /> | ||
*'''AKR2E4''' is involved in regulation of the molting hormone ecdysone<ref>PMID:24012638</ref>.<br /> | *'''AKR2E4''' is involved in regulation of the molting hormone ecdysone<ref>PMID:24012638</ref>.<br /> | ||
| - | *'''AKR4C8''' and '''AKR4C9''' detoxify sugar-derived reactive carbonyls<ref>PMID: | + | *'''AKR4C8''' and '''AKR4C9''' detoxify sugar-derived reactive carbonyls<ref>PMID:24096666</ref>.<br /> |
== Disease == | == Disease == | ||
Revision as of 09:12, 22 May 2024
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References
- ↑ Penning TM. The aldo-keto reductases (AKRs): Overview. Chem Biol Interact. 2015 Jun 5;234:236-46. doi: 10.1016/j.cbi.2014.09.024. Epub, 2014 Oct 7. PMID:25304492 doi:http://dx.doi.org/10.1016/j.cbi.2014.09.024
- ↑ Brožič P, Turk S, Rižner TL, Gobec S. Inhibitors of aldo-keto reductases AKR1C1-AKR1C4. Curr Med Chem. 2011;18(17):2554-65. PMID:21568892 doi:10.2174/092986711795933713
- ↑ . PMID:110526179
- ↑ Yamamoto K, Wilson DK. Identification, characterization, and crystal structure of an aldo-keto reductase (AKR2E4) from the silkworm Bombyx mori. Arch Biochem Biophys. 2013 Oct 15;538(2):156-63. doi: 10.1016/j.abb.2013.08.018. , Epub 2013 Sep 6. PMID:24012638 doi:http://dx.doi.org/10.1016/j.abb.2013.08.018
- ↑ Saito R, Shimakawa G, Nishi A, Iwamoto T, Sakamoto K, Yamamoto H, Amako K, Makino A, Miyake C. Functional analysis of the AKR4C subfamily of Arabidopsis thaliana: model structures, substrate specificity, acrolein toxicity, and responses to light and [CO(2)]. Biosci Biotechnol Biochem. 2013;77(10):2038-45. PMID:24096666 doi:10.1271/bbb.130353
- ↑ Drury JE, Mindnich R, Penning TM. Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency. J Biol Chem. 2010 Aug 6;285(32):24529-37. doi: 10.1074/jbc.M110.127779. Epub 2010, Jun 3. PMID:20522910 doi:http://dx.doi.org/10.1074/jbc.M110.127779
- ↑ Cousido-Siah A, Ruiz FX, Mitschler A, Porte S, de Lera AR, Martin MJ, Manzanaro S, de la Fuente JA, Terwesten F, Betz M, Klebe G, Farres J, Pares X, Podjarny A. Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):889-903. doi:, 10.1107/S1399004713033452. Epub 2014 Feb 27. PMID:24598757 doi:http://dx.doi.org/10.1107/S1399004713033452
