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2kdt

From Proteopedia

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==PC1/3 DCSG sorting domain structure in DPC==
==PC1/3 DCSG sorting domain structure in DPC==
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<StructureSection load='2kdt' size='340' side='right' caption='[[2kdt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kdt' size='340' side='right'caption='[[2kdt]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KDT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kdt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KDT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pcsk1, Att-1, Nec-1, Nec1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proprotein_convertase_1 Proprotein convertase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.93 3.4.21.93] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdt OCA], [https://pdbe.org/2kdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kdt RCSB], [https://www.ebi.ac.uk/pdbsum/2kdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kdt ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kdt RCSB], [http://www.ebi.ac.uk/pdbsum/2kdt PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEC1_MOUSE NEC1_MOUSE] Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kdt_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kdt_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kdt ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2kdt" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Proprotein convertase 1]]
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[[Category: Di Lello P]]
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[[Category: Dikeakos, J D.]]
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[[Category: Dikeakos JD]]
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[[Category: Ghirlando, R.]]
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[[Category: Ghirlando R]]
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[[Category: Lacombe, M J.]]
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[[Category: Lacombe MJ]]
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[[Category: Legault, P.]]
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[[Category: Legault P]]
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[[Category: Lello, P Di.]]
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[[Category: Omichinski JG]]
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[[Category: Omichinski, J G.]]
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[[Category: Reudelhuber TL]]
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[[Category: Reudelhuber, T L.]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Prohorme convertase]]
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[[Category: Protease]]
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[[Category: Protein transport]]
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[[Category: Secretory granule]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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Current revision

PC1/3 DCSG sorting domain structure in DPC

PDB ID 2kdt

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