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4wh8
From Proteopedia
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<StructureSection load='4wh8' size='340' side='right'caption='[[4wh8]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='4wh8' size='340' side='right'caption='[[4wh8]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wh8]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4wh8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WH8 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M7:TERT-BUTYL+[(2R,6S,12Z,13AS,14AR,16AS)-2-[(7-CHLORO-4-METHOXYISOQUINOLIN-1-YL)OXY]-14A-{[CYCLOPROPYL(DIHYDROXY)-LAMBDA~4~-SULFANYL]CARBAMOYL}-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-6-YL]CARBAMATE'>3M7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3M7:TERT-BUTYL+[(2R,6S,12Z,13AS,14AR,16AS)-2-[(7-CHLORO-4-METHOXYISOQUINOLIN-1-YL)OXY]-14A-{[CYCLOPROPYL(DIHYDROXY)-LAMBDA~4~-SULFANYL]CARBAMOYL}-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-6-YL]CARBAMATE'>3M7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wh8 OCA], [https://pdbe.org/4wh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wh8 RCSB], [https://www.ebi.ac.uk/pdbsum/4wh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wh8 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A8DG50_9HEPC A8DG50_9HEPC] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Hepatitis | + | [[Category: Hepatitis C virus genotype 1a]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ali | + | [[Category: Ali A]] |
| - | [[Category: Schiffer | + | [[Category: Schiffer CA]] |
| - | [[Category: Soumana | + | [[Category: Soumana DI]] |
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Current revision
Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.
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