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6rvy
From Proteopedia
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==Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate== | ==Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate== | ||
| - | < | + | <SX load='6rvy' size='340' side='right' viewer='molstar' caption='[[6rvy]], [[Resolution|resolution]] 4.13Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6rvy]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6rvy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RVY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.13Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvy OCA], [https://pdbe.org/6rvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rvy RCSB], [https://www.ebi.ac.uk/pdbsum/6rvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvy ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/AAAT_HUMAN AAAT_HUMAN] Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).<ref>PMID:10708449</ref> <ref>PMID:23492904</ref> <ref>PMID:8702519</ref> (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.<ref>PMID:10051606</ref> <ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.<ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.<ref>PMID:10196349</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Garaeva | + | [[Category: Garaeva AA]] |
| - | [[Category: Guskov | + | [[Category: Guskov A]] |
| - | [[Category: Paulino | + | [[Category: Paulino C]] |
| - | [[Category: Slotboom | + | [[Category: Slotboom DJ]] |
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Current revision
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate
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