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6s8h

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Current revision (10:14, 22 May 2024) (edit) (undo)
 
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<SX load='6s8h' size='340' side='right' viewer='molstar' caption='[[6s8h]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<SX load='6s8h' size='340' side='right' viewer='molstar' caption='[[6s8h]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6s8h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S8H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6s8h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S8H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCQ:2-DECYL-5,6-DIMETHOXY-3-METHYLCYCLOHEXA-2,5-DIENE-1,4-DIONE'>DCQ</scene>, <scene name='pdbligand=JSG:(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic+acid'>JSG</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6s8g|6s8g]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCQ:2-DECYL-5,6-DIMETHOXY-3-METHYLCYCLOHEXA-2,5-DIENE-1,4-DIONE'>DCQ</scene>, <scene name='pdbligand=JSG:(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic+acid'>JSG</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SGF_01136 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927]), lptF, SF4228, S4489 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927]), yjgQ, S4488, CQA91_25110, NCTC9783_00309, SAMEA3710568_03584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8h OCA], [https://pdbe.org/6s8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s8h RCSB], [https://www.ebi.ac.uk/pdbsum/6s8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8h ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8h OCA], [http://pdbe.org/6s8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8h RCSB], [http://www.ebi.ac.uk/pdbsum/6s8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8h ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LPTF_SHIFL LPTF_SHIFL]] Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
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[https://www.uniprot.org/uniprot/LPTF_SHIFL LPTF_SHIFL] Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Shigella paradysenteriae weldin 1927]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chang, S H]]
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[[Category: Shigella flexneri]]
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[[Category: Dong, C J]]
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[[Category: Chang SH]]
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[[Category: Dong, H H]]
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[[Category: Dong CJ]]
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[[Category: Luo, Q H]]
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[[Category: Dong HH]]
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[[Category: Niu, Y]]
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[[Category: Luo QH]]
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[[Category: Qiao, W]]
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[[Category: Niu Y]]
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[[Category: Tang, X D]]
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[[Category: Qiao W]]
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[[Category: Wang, T]]
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[[Category: Tang XD]]
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[[Category: Xu, C H]]
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[[Category: Wang T]]
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[[Category: Yang, W X]]
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[[Category: Xu CH]]
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[[Category: Zhang, C B]]
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[[Category: Yang WX]]
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[[Category: Zhang, X]]
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[[Category: Zhang CB]]
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[[Category: Zhang, Z B]]
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[[Category: Zhang X]]
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[[Category: Zhang, Z Y]]
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[[Category: Zhang ZB]]
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[[Category: Zhu, X F]]
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[[Category: Zhang ZY]]
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[[Category: Abc transporter]]
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[[Category: Zhu XF]]
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[[Category: Gram-negative bacteria]]
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[[Category: Inner membrane protein complex]]
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[[Category: Lipopolysaccharide transporter]]
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[[Category: Lp]]
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[[Category: Lptb]]
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[[Category: Lptb2fgc]]
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[[Category: Lptbfg]]
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[[Category: Outer membrane]]
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[[Category: Transport protein]]
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Current revision

Cryo-EM structure of LptB2FG in complex with LPS

6s8h, resolution 3.70Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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