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6t7a

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Current revision (10:17, 22 May 2024) (edit) (undo)
 
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<StructureSection load='6t7a' size='340' side='right'caption='[[6t7a]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='6t7a' size='340' side='right'caption='[[6t7a]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6t7a]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T7A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T7A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6t7a]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T7A FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6t78|6t78]], [[6t79|6t79]], [[6t7b|6t7b]], [[6t7c|6t7c]], [[6t7d|6t7d]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HIST2H3A, HIST2H3C, H3F2, H3FM, HIST2H3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BK, H2BFT, HIRIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SOX11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t7a OCA], [https://pdbe.org/6t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t7a RCSB], [https://www.ebi.ac.uk/pdbsum/6t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t7a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t7a OCA], [http://pdbe.org/6t7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t7a RCSB], [http://www.ebi.ac.uk/pdbsum/6t7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t7a ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/SOX11_HUMAN SOX11_HUMAN]] Coffin-Siris syndrome. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H2B1K_HUMAN H2B1K_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. [[http://www.uniprot.org/uniprot/SOX11_HUMAN SOX11_HUMAN]] Transcription factor that acts as a transcriptional activator (PubMed:24886874). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).[UniProtKB:Q7M6Y2]<ref>PMID:24886874</ref>
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[https://www.uniprot.org/uniprot/H32_HUMAN H32_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6t7a" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6t7a" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cramer, P]]
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[[Category: Synthetic construct]]
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[[Category: Dienemann, C]]
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[[Category: Cramer P]]
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[[Category: Dodonova, S O]]
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[[Category: Dienemann C]]
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[[Category: Taipale, J]]
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[[Category: Dodonova SO]]
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[[Category: Zhu, F]]
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[[Category: Taipale J]]
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[[Category: Dna]]
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[[Category: Zhu F]]
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[[Category: Histone]]
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[[Category: Nuclear protein]]
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[[Category: Nucleosome]]
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[[Category: Pioneer factor]]
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[[Category: Sox11]]
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[[Category: Transcription factor]]
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Current revision

Structure of human Sox11 transcription factor in complex with a nucleosome

PDB ID 6t7a

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