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7qe7

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'''Unreleased structure'''
 
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The entry 7qe7 is ON HOLD
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==High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1==
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<StructureSection load='7qe7' size='340' side='right'caption='[[7qe7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Hoefler, A., Yu, J., Chang, L., Zhang, Z., Yang, J., Boland, A., Barford, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7qe7]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QE7 FirstGlance]. <br>
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Description: High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Boland, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qe7 OCA], [https://pdbe.org/7qe7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qe7 RCSB], [https://www.ebi.ac.uk/pdbsum/7qe7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qe7 ProSAT]</span></td></tr>
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[[Category: Barford, D]]
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</table>
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[[Category: Yang, J]]
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== Function ==
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[[Category: Zhang, Z]]
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[https://www.uniprot.org/uniprot/APC10_HUMAN APC10_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref>
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[[Category: Hoefler, A]]
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== References ==
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[[Category: Chang, L]]
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<references/>
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[[Category: Yu, J]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Barford D]]
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[[Category: Boland A]]
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[[Category: Chang L]]
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[[Category: Hoefler A]]
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[[Category: Yang J]]
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[[Category: Yu J]]
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[[Category: Zhang Z]]

Current revision

High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1

PDB ID 7qe7

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