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2b69

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==Crystal Structure of Human UDP-glucoronic acid decarboxylase==
==Crystal Structure of Human UDP-glucoronic acid decarboxylase==
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<StructureSection load='2b69' size='340' side='right' caption='[[2b69]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
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<StructureSection load='2b69' size='340' side='right'caption='[[2b69]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2b69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B69 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2b69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B69 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UXS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b69 OCA], [https://pdbe.org/2b69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b69 RCSB], [https://www.ebi.ac.uk/pdbsum/2b69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b69 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucuronate_decarboxylase UDP-glucuronate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.35 4.1.1.35] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b69 OCA], [http://pdbe.org/2b69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b69 RCSB], [http://www.ebi.ac.uk/pdbsum/2b69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b69 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UXS1_HUMAN UXS1_HUMAN]] Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
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[https://www.uniprot.org/uniprot/UXS1_HUMAN UXS1_HUMAN] Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: UDP-glucuronate decarboxylase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F von]]
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[[Category: Dubinina E]]
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[[Category: Dubinina, E]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Sundstrom M]]
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[[Category: Structural genomic]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Lyase]]
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[[Category: Sgc]]
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[[Category: Udp-glucoronic acid decarboxylase]]
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Current revision

Crystal Structure of Human UDP-glucoronic acid decarboxylase

PDB ID 2b69

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