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2bvr
From Proteopedia
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| - | [[Image:2bvr.gif|left|200px]]<br /> | ||
| - | <applet load="2bvr" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2bvr, resolution 1.25Å" /> | ||
| - | '''HUMAN THROMBIN COMPLEXED WITH FRAGMENT-BASED SMALL MOLECULES OCCUPYING THE S1 POCKET'''<br /> | ||
| - | == | + | ==Human thrombin complexed with fragment-based small molecules occupying the S1 pocket== |
| - | + | <StructureSection load='2bvr' size='340' side='right'caption='[[2bvr]], [[Resolution|resolution]] 1.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2bvr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BVR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4CP:2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE'>4CP</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bvr OCA], [https://pdbe.org/2bvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bvr RCSB], [https://www.ebi.ac.uk/pdbsum/2bvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bvr ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/HIRV2_HIRME HIRV2_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. | |
| - | [ | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [[ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/2bvr_consurf.spt"</scriptWhenChecked> | |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bvr ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | + | ==See Also== | |
| + | *[[Hirudin 3D structures|Hirudin 3D structures]] | ||
| + | *[[Thrombin 3D Structures|Thrombin 3D Structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hirudo medicinalis]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Burkert K]] | ||
| + | [[Category: Deppe H]] | ||
| + | [[Category: Feurer A]] | ||
| + | [[Category: Gamer J]] | ||
| + | [[Category: Junker H-D]] | ||
| + | [[Category: Keil O]] | ||
| + | [[Category: Metz G]] | ||
| + | [[Category: Neumann T]] | ||
| + | [[Category: Ottleben H]] | ||
| + | [[Category: Sekul R]] | ||
| + | [[Category: Tomandl D]] | ||
Current revision
Human thrombin complexed with fragment-based small molecules occupying the S1 pocket
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Categories: Hirudo medicinalis | Homo sapiens | Large Structures | Burkert K | Deppe H | Feurer A | Gamer J | Junker H-D | Keil O | Metz G | Neumann T | Ottleben H | Sekul R | Tomandl D
