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2cit

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{{Seed}}
 
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[[Image:2cit.png|left|200px]]
 
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==Structure of the covalent intermediate of a family 26 lichenase==
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The line below this paragraph, containing "STRUCTURE_2cit", creates the "Structure Box" on the page.
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<StructureSection load='2cit' size='340' side='right'caption='[[2cit]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=G2F:2-DEOXY-2-FLUORO-ALPHA-D-GLUCOPYRANOSE'>G2F</scene></td></tr>
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{{STRUCTURE_2cit| PDB=2cit | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cit OCA], [https://pdbe.org/2cit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cit RCSB], [https://www.ebi.ac.uk/pdbsum/2cit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cit ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GUNH_ACET2 GUNH_ACET2] This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cit_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cit ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF THE COVALENT INTERMEDIATE OF A FAMILY 26 LICHENASE===
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==See Also==
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*[[Glucanase 3D structures|Glucanase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2CIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIT OCA].
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[[Category: Acetivibrio thermocellus]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Davies GJ]]
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Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases., Money VA, Smith NL, Scaffidi A, Stick RV, Gilbert HJ, Davies GJ, Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5136-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16823793 16823793]
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[[Category: Gilbert HJ]]
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[[Category: Cellulase]]
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[[Category: Money VA]]
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[[Category: Clostridium thermocellum]]
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[[Category: Scaffidi A]]
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[[Category: Single protein]]
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[[Category: Smith NL]]
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[[Category: Davies, G J.]]
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[[Category: Stick RV]]
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[[Category: Gilbert, H J.]]
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[[Category: Money, V A.]]
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[[Category: Scaffidi, A.]]
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[[Category: Smith, N L.]]
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[[Category: Stick, R V.]]
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[[Category: Beta-1,4 beta-1,3 glucanase]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Cellulose degradation]]
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[[Category: Glycosidase]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Lichenase]]
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[[Category: Michaelis complex]]
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[[Category: Polysaccharide degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:52:01 2008''
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Current revision

Structure of the covalent intermediate of a family 26 lichenase

PDB ID 2cit

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