This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ctx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:30, 22 May 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='2ctx' size='340' side='right'caption='[[2ctx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2ctx' size='340' side='right'caption='[[2ctx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://pdbe.org/2ctx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctx ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [https://pdbe.org/2ctx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [https://www.ebi.ac.uk/pdbsum/2ctx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NXL3_NAJNA NXL3_NAJNA]] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).
+
[https://www.uniprot.org/uniprot/3L23_NAJNA 3L23_NAJNA] Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 31: Line 32:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Indian cobra]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Betzel, C]]
+
[[Category: Naja naja]]
-
[[Category: Lange, G]]
+
[[Category: Betzel C]]
-
[[Category: Maelicke, A]]
+
[[Category: Lange G]]
-
[[Category: Pal, G P]]
+
[[Category: Maelicke A]]
-
[[Category: Saenger, W]]
+
[[Category: Pal GP]]
-
[[Category: Wilson, K S]]
+
[[Category: Saenger W]]
-
[[Category: Neurotoxin]]
+
[[Category: Wilson KS]]

Current revision

THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION

PDB ID 2ctx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ctx"
Personal tools