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2cud

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Current revision (11:31, 22 May 2024) (edit) (undo)
 
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==Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)==
==Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)==
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<StructureSection load='2cud' size='340' side='right'caption='[[2cud]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2cud' size='340' side='right'caption='[[2cud]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUD FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cud OCA], [https://pdbe.org/2cud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cud RCSB], [https://www.ebi.ac.uk/pdbsum/2cud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cud ProSAT], [https://www.topsan.org/Proteins/RSGI/2cud TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cud OCA], [https://pdbe.org/2cud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cud RCSB], [https://www.ebi.ac.uk/pdbsum/2cud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cud ProSAT], [https://www.topsan.org/Proteins/RSGI/2cud TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SLAP1_HUMAN SLAP1_HUMAN]] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.<ref>PMID:11696592</ref> <ref>PMID:10449770</ref>
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[https://www.uniprot.org/uniprot/SLAP1_HUMAN SLAP1_HUMAN] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.<ref>PMID:11696592</ref> <ref>PMID:10449770</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Nameki, N]]
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[[Category: Nameki N]]
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[[Category: Ohnishi, S]]
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[[Category: Ohnishi S]]
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[[Category: Structural genomic]]
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[[Category: Sato M]]
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[[Category: Sato, M]]
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[[Category: Tochio N]]
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[[Category: Tochio, N]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Negative mitogenesis regulator]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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Current revision

Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)

PDB ID 2cud

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