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2cv8

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[[Image:2cv8.gif|left|200px]]
 
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{{Structure
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==Crystal structure of tRNA-intron endonuclease from Sulfolobus tokodaii==
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|PDB= 2cv8 |SIZE=350|CAPTION= <scene name='initialview01'>2cv8</scene>, resolution 2.80&Aring;
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<StructureSection load='2cv8' size='340' side='right'caption='[[2cv8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2cv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CV8 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-intron_endonuclease tRNA-intron endonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.9 3.1.27.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cv8 OCA], [https://pdbe.org/2cv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cv8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cv8 TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cv8 OCA], [http://www.ebi.ac.uk/pdbsum/2cv8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cv8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/ENDA_SULTO ENDA_SULTO] Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/2cv8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cv8 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of tRNA-intron endonuclease from Sulfolobus tokodaii'''
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2CV8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CV8 OCA].
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Sulfurisphaera tokodaii]]
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[[Category: Sulfolobus tokodaii]]
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[[Category: Bessho Y]]
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[[Category: tRNA-intron endonuclease]]
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[[Category: Kato-Murayama M]]
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[[Category: Bessho, Y.]]
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[[Category: Shirouzu M]]
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[[Category: Kato-Murayama, M.]]
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[[Category: Yokoyama S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu, M.]]
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[[Category: Yokoyama, S.]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: trna splicing]]
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[[Category: trna-intron endonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:26:48 2008''
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Current revision

Crystal structure of tRNA-intron endonuclease from Sulfolobus tokodaii

PDB ID 2cv8

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