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2cz2

From Proteopedia

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[[Image:2cz2.gif|left|200px]]
 
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{{Structure
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==Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from Mus musculus (form-1 crystal)==
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|PDB= 2cz2 |SIZE=350|CAPTION= <scene name='initialview01'>2cz2</scene>, resolution 1.40&Aring;
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<StructureSection load='2cz2' size='340' side='right'caption='[[2cz2]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2cz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ2 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz2 OCA], [https://pdbe.org/2cz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz2 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz2 TOPSAN]</span></td></tr>
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|RELATEDENTRY=[[2cz3|2CZ3]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz2 OCA], [http://www.ebi.ac.uk/pdbsum/2cz2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cz2 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/MAAI_MOUSE MAAI_MOUSE] Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2cz2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cz2 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from Mus musculus (form-1 crystal)'''
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2CZ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ2 OCA].
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Kinoshita Y]]
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[[Category: Kinoshita, Y.]]
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[[Category: Mizohata E]]
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[[Category: Mizohata, E.]]
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[[Category: Morita S]]
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[[Category: Morita, S.]]
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[[Category: Nagano K]]
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[[Category: Nagano, K.]]
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[[Category: Shirouzu M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Uchikubo T]]
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[[Category: Shirouzu, M.]]
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[[Category: Uda H]]
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[[Category: Uchikubo, T.]]
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[[Category: Yokoyama S]]
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[[Category: Uda, H.]]
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[[Category: Yokoyama, S.]]
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[[Category: gst]]
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[[Category: gstz1-1]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:28:15 2008''
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Current revision

Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from Mus musculus (form-1 crystal)

PDB ID 2cz2

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