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2d8v

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==Solution structure of the B-box domain of the zinc finger FYVE domain-containing protein 19 from Mus musculus==
==Solution structure of the B-box domain of the zinc finger FYVE domain-containing protein 19 from Mus musculus==
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<StructureSection load='2d8v' size='340' side='right' caption='[[2d8v]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2d8v' size='340' side='right'caption='[[2d8v]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2d8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D8V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2d8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Zfyve19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8v OCA], [http://pdbe.org/2d8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d8v RCSB], [http://www.ebi.ac.uk/pdbsum/2d8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8v ProSAT], [http://www.topsan.org/Proteins/RSGI/2d8v TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8v OCA], [https://pdbe.org/2d8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8v RCSB], [https://www.ebi.ac.uk/pdbsum/2d8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8v ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8v TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ANCHR_MOUSE ANCHR_MOUSE]] Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity).
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[https://www.uniprot.org/uniprot/ANCHR_MOUSE ANCHR_MOUSE] Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Mus musculus]]
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[[Category: Kigawa, T]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S]]
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[[Category: Kigawa T]]
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[[Category: Miyamoto, K]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Miyamoto K]]
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[[Category: Sato, M]]
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[[Category: Sato M]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Metal binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Zf-b_box]]
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[[Category: Zfyve19]]
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[[Category: Zinc finger fyve domain-containing protein 19]]
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Current revision

Solution structure of the B-box domain of the zinc finger FYVE domain-containing protein 19 from Mus musculus

PDB ID 2d8v

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