2d8z
From Proteopedia
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| - | [[Image:2d8z.gif|left|200px]]<br /><applet load="2d8z" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2d8z" /> | ||
| - | '''Solution structure of the third LIM domain of Four and a half LIM domains protein 2 (FHL-2)'''<br /> | ||
| - | == | + | ==Solution structure of the third LIM domain of Four and a half LIM domains protein 2 (FHL-2)== |
| - | + | <StructureSection load='2d8z' size='340' side='right'caption='[[2d8z]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | [ | + | <table><tr><td colspan='2'>[[2d8z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8Z FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8z OCA], [https://pdbe.org/2d8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8z RCSB], [https://www.ebi.ac.uk/pdbsum/2d8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8z ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8z TOPSAN]</span></td></tr> | |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/FHL2_HUMAN FHL2_HUMAN] May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.<ref>PMID:15692560</ref> <ref>PMID:16652157</ref> <ref>PMID:18853468</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | [[ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/2d8z_consurf.spt"</scriptWhenChecked> |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d8z ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Muscle LIM protein|Muscle LIM protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hayashi F]] | ||
| + | [[Category: Qin XR]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Solution structure of the third LIM domain of Four and a half LIM domains protein 2 (FHL-2)
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