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2da2

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(New page: 200px<br /> <applet load="2da2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2da2" /> '''Solution structure of the second homeobox d...)
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[[Image:2da2.gif|left|200px]]<br />
 
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<applet load="2da2" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2da2" />
 
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'''Solution structure of the second homeobox domain of AT-binding transcription factor 1 (ATBF1)'''<br />
 
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==Disease==
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==Solution structure of the second homeobox domain of AT-binding transcription factor 1 (ATBF1)==
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Known disease associated with this structure: Prostate cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104155 104155]]
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<StructureSection load='2da2' size='340' side='right'caption='[[2da2]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2da2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DA2 FirstGlance]. <br>
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2DA2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DA2 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2da2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2da2 OCA], [https://pdbe.org/2da2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2da2 RCSB], [https://www.ebi.ac.uk/pdbsum/2da2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2da2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2da2 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZFHX3_HUMAN ZFHX3_HUMAN] Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.<ref>PMID:11312261</ref> <ref>PMID:17330845</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2da2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2da2 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: Ohnishi, S.]]
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[[Category: Ohnishi S]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: homeobox domain]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: three helices with the dna binding helix-turn-helix motif]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:29:03 2007''
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Current revision

Solution structure of the second homeobox domain of AT-binding transcription factor 1 (ATBF1)

PDB ID 2da2

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