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2dak

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(New page: 200px<br /> <applet load="2dak" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dak" /> '''Solution Structure of the Second UBA Domain...)
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[[Image:2dak.gif|left|200px]]<br />
 
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<applet load="2dak" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dak" />
 
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'''Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)'''<br />
 
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==About this Structure==
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==Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)==
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2DAK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DAK OCA].
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<StructureSection load='2dak' size='340' side='right'caption='[[2dak]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2dak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAK FirstGlance]. <br>
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[[Category: Ubiquitin thiolesterase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Inoue, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dak OCA], [https://pdbe.org/2dak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dak RCSB], [https://www.ebi.ac.uk/pdbsum/2dak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dak ProSAT], [https://www.topsan.org/Proteins/RSGI/2dak TOPSAN]</span></td></tr>
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[[Category: Kigawa, T.]]
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</table>
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[[Category: Koshiba, S.]]
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== Function ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/UBP5_HUMAN UBP5_HUMAN] Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.<ref>PMID:19098288</ref>
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[[Category: Sato, M.]]
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== Evolutionary Conservation ==
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[[Category: Yokoyama, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Zhao, C.]]
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Check<jmol>
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[[Category: isopeptidase t]]
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<jmolCheckbox>
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[[Category: national project on protein structural and functional analyses]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2dak_consurf.spt"</scriptWhenChecked>
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[[Category: nppsfa]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: riken structural genomics/proteomics initiative]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: rsgi]]
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</jmolCheckbox>
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[[Category: structural genomics ]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dak ConSurf].
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[[Category: uba domain]]
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<div style="clear:both"></div>
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[[Category: ubiquitin specific protease 5]]
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[[Category: usp 5]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:29:35 2007''
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Sato M]]
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[[Category: Yokoyama S]]
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[[Category: Zhao C]]

Current revision

Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)

PDB ID 2dak

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