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2db7
From Proteopedia
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| - | [[Image:2db7.jpg|left|200px]]<br /><applet load="2db7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2db7, resolution 1.90Å" /> | ||
| - | '''Crystal structure of hypothetical protein MS0332'''<br /> | ||
| - | == | + | ==Crystal structure of hypothetical protein MS0332== |
| - | + | <StructureSection load='2db7' size='340' side='right'caption='[[2db7]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2db7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DB7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2db7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2db7 OCA], [https://pdbe.org/2db7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2db7 RCSB], [https://www.ebi.ac.uk/pdbsum/2db7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2db7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2db7 TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HEY1_HUMAN HEY1_HUMAN] Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.<ref>PMID:11095750</ref> <ref>PMID:15485867</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2db7_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2db7 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Murayama | + | [[Category: Murayama K]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Takemoto-Hori C]] |
| - | [[Category: Takemoto-Hori | + | [[Category: Terada T]] |
| - | [[Category: Terada | + | [[Category: Wang H]] |
| - | [[Category: Wang | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Crystal structure of hypothetical protein MS0332
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