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2dhr

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==Whole cytosolic region of ATP-dependent metalloprotease FtsH (G399L)==
==Whole cytosolic region of ATP-dependent metalloprotease FtsH (G399L)==
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<StructureSection load='2dhr' size='340' side='right' caption='[[2dhr]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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<StructureSection load='2dhr' size='340' side='right'caption='[[2dhr]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2dhr]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2dhr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ixz|1ixz]], [[1iy0|1iy0]], [[1iy1|1iy1]], [[1iy2|1iy2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhr OCA], [http://pdbe.org/2dhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dhr RCSB], [http://www.ebi.ac.uk/pdbsum/2dhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhr OCA], [https://pdbe.org/2dhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhr RCSB], [https://www.ebi.ac.uk/pdbsum/2dhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FTSH_THET8 FTSH_THET8]] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458] Degrades preferentially unfolded substrates in a processive, ATP-dependent manner, usually after hydrophobic residues.[HAMAP-Rule:MF_01458]
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[https://www.uniprot.org/uniprot/FTSH_THET8 FTSH_THET8] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458] Degrades preferentially unfolded substrates in a processive, ATP-dependent manner, usually after hydrophobic residues.[HAMAP-Rule:MF_01458]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
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[[Category: Large Structures]]
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[[Category: Morikawa, K]]
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[[Category: Thermus thermophilus]]
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[[Category: Niwa, H]]
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[[Category: Morikawa K]]
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[[Category: Suno, R]]
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[[Category: Niwa H]]
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[[Category: Tsuchiya, D]]
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[[Category: Suno R]]
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[[Category: Yoshida, M]]
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[[Category: Tsuchiya D]]
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[[Category: Zhang, X]]
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[[Category: Yoshida M]]
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[[Category: Aaa+ protein]]
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[[Category: Zhang X]]
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[[Category: Hexameric zn metalloprotease]]
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[[Category: Hydrolase]]
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Current revision

Whole cytosolic region of ATP-dependent metalloprotease FtsH (G399L)

PDB ID 2dhr

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