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Arrestin

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*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.
*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.
*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.
*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.
 +
*'''Arrestin-3''' or '''cone arrestin'''
== Structural highlights ==
== Structural highlights ==

Revision as of 09:22, 28 May 2024

Bovine arrestin-2 complex with Ba+2 ions (PDB code 2wtr)

Drag the structure with the mouse to rotate

References

  1. Hirsch JA, Schubert C, Gurevich VV, Sigler PB. The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation. Cell. 1999 Apr 16;97(2):257-69. PMID:10219246
  2. Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J. β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun. 2017 Feb 1;8:14295. PMID:28145434 doi:10.1038/ncomms14295
  3. Zheng C, Weinstein LD, Nguyen KK, Grewal A, Gurevich EV, Gurevich VV. GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements. Cells. 2023 Jun 6;12(12):1563. PMID:37371033 doi:10.3390/cells12121563

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Michal Harel, Alexander Berchansky

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