1sg7
From Proteopedia
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'''NMR solution structure of the putative cation transport regulator ChaB''' | '''NMR solution structure of the putative cation transport regulator ChaB''' | ||
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[[Category: Osborne, M J.]] | [[Category: Osborne, M J.]] | ||
[[Category: Siddiqui, N.]] | [[Category: Siddiqui, N.]] | ||
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| - | [[Category: | + | [[Category: Montreal-kingston bacterial structural genomics initiative]] |
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:39:56 2008'' | |
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Revision as of 05:39, 3 May 2008
NMR solution structure of the putative cation transport regulator ChaB
Overview
BACKGROUND: ChaB is a putative regulator of ChaA, a Na+/H+ antiporter that also has Ca+/H+ activity in E. coli. ChaB contains a conserved 60-residue region of unknown function found in other bacteria, archaeabacteria and a series of baculoviral proteins. As part of a structural genomics project, the structure of ChaB was elucidated by NMR spectroscopy. RESULTS: The structure of ChaB is composed of 3 alpha-helices and a small sheet that pack tightly to form a fold that is found in the cyclin-box family of proteins. CONCLUSION: ChaB is distinguished from its putative DNA binding sequence homologues by a highly charged flexible loop region that has weak affinity to Mg2+ and Ca2+ divalent metal ions.
About this Structure
1SG7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli., Osborne MJ, Siddiqui N, Iannuzzi P, Gehring K, BMC Struct Biol. 2004 Aug 11;4:9. PMID:15306028 Page seeded by OCA on Sat May 3 08:39:56 2008
