1q1v

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{{Seed}}
 
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[[Image:1q1v.png|left|200px]]
 
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==Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif==
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The line below this paragraph, containing "STRUCTURE_1q1v", creates the "Structure Box" on the page.
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<StructureSection load='1q1v' size='340' side='right'caption='[[1q1v]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1v OCA], [https://pdbe.org/1q1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1v RCSB], [https://www.ebi.ac.uk/pdbsum/1q1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1v ProSAT]</span></td></tr>
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{{STRUCTURE_1q1v| PDB=1q1v | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DEK_HUMAN DEK_HUMAN] Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.
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== Function ==
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[https://www.uniprot.org/uniprot/DEK_HUMAN DEK_HUMAN] Involved in chromatin organization.<ref>PMID:17524367</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q1v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The chromatin-associated protein DEK was first identified as a fusion protein in patients with a subtype of acute myelogenous leukemia. It has since become associated with diverse human ailments ranging from cancers to autoimmune diseases. Despite much research effort, the biochemical basis for these clinical connections has yet to be explained. We have identified a structural domain in the C-terminal region of DEK [DEK(309-375)]. DEK(309-375) implies clinical importance because it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. We determined the solution structure of DEK(309-375) by nuclear magnetic resonance spectroscopy, and found it to be structurally homologous to the E2F/DP transcription factor family. On the basis of this homology, we tested whether DEK(309-375) could bind DNA and identified the DNA-interacting surface. DEK presents a hydrophobic surface on the side opposite the DNA-interacting surface. The structure of the C-terminal region of DEK provides insights into the protein function of DEK.
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===Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif===
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Solution NMR structure of the C-terminal domain of the human protein DEK.,Devany M, Kotharu NP, Matsuo H Protein Sci. 2004 Aug;13(8):2252-9. Epub 2004 Jul 6. PMID:15238633<ref>PMID:15238633</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15238633}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1q1v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15238633 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15238633}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Q1V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1V OCA].
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==Reference==
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Solution NMR structure of the C-terminal domain of the human protein DEK., Devany M, Kotharu NP, Matsuo H, Protein Sci. 2004 Aug;13(8):2252-9. Epub 2004 Jul 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15238633 15238633]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Devany, M.]]
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[[Category: Devany M]]
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[[Category: Kotharu, N P.]]
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[[Category: Kotharu NP]]
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[[Category: Matsuo, H.]]
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[[Category: Matsuo H]]
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[[Category: Winged-helix motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:02:55 2008''
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Current revision

Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif

PDB ID 1q1v

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