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1v38
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==Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1== | ==Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1== | ||
| - | <StructureSection load='1v38' size='340' side='right' caption='[[1v38 | + | <StructureSection load='1v38' size='340' side='right'caption='[[1v38]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1v38]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1v38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V38 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v38 OCA], [https://pdbe.org/1v38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v38 RCSB], [https://www.ebi.ac.uk/pdbsum/1v38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v38 ProSAT], [https://www.topsan.org/Proteins/RSGI/1v38 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SAMN1_MOUSE SAMN1_MOUSE] Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.<ref>PMID:15381729</ref> <ref>PMID:19923443</ref> <ref>PMID:20478393</ref> <ref>PMID:21296879</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Goroncy | + | [[Category: Mus musculus]] |
| - | [[Category: Inoue | + | [[Category: Goroncy A]] |
| - | [[Category: Kigawa | + | [[Category: Inoue M]] |
| - | [[Category: Kobayashi | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Kobayashi N]] |
| - | + | [[Category: Koshiba S]] | |
| - | [[Category: Tochio | + | [[Category: Tochio N]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1
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Categories: Large Structures | Mus musculus | Goroncy A | Inoue M | Kigawa T | Kobayashi N | Koshiba S | Tochio N | Yokoyama S
