1x59

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[[Image:1x59.png|left|200px]]
 
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{{STRUCTURE_1x59| PDB=1x59 | SCENE= }}
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==Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase==
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<StructureSection load='1x59' size='340' side='right'caption='[[1x59]]' scene=''>
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===Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X59 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x59 OCA], [https://pdbe.org/1x59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x59 RCSB], [https://www.ebi.ac.uk/pdbsum/1x59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x59 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x59 TOPSAN]</span></td></tr>
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[[1x59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X59 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Autosomal dominant Charcot-Marie-Tooth disease type 2W;Usher syndrome type 3. The disease may be caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).<ref>PMID:26072516</ref> <ref>PMID:29235198</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x59_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x59 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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[[Category: Histidine--tRNA ligase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: Nameki, N.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nameki N]]
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[[Category: Sasagawa, A.]]
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[[Category: Sasagawa A]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Hisr]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Protein binding]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase

PDB ID 1x59

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