1x59

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(New page: 200px<br /> <applet load="1x59" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x59" /> '''Solution structures of the WHEP-TRS domain ...)
Current revision (18:26, 29 May 2024) (edit) (undo)
 
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[[Image:1x59.gif|left|200px]]<br />
 
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<applet load="1x59" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1x59" />
 
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'''Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase'''<br />
 
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==About this Structure==
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==Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase==
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1X59 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X59 OCA].
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<StructureSection load='1x59' size='340' side='right'caption='[[1x59]]' scene=''>
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[[Category: Histidine--tRNA ligase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[1x59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X59 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Inoue, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x59 OCA], [https://pdbe.org/1x59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x59 RCSB], [https://www.ebi.ac.uk/pdbsum/1x59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x59 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x59 TOPSAN]</span></td></tr>
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[[Category: Kigawa, T.]]
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</table>
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[[Category: Koshiba, S.]]
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== Disease ==
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[[Category: Nameki, N.]]
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[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Autosomal dominant Charcot-Marie-Tooth disease type 2W;Usher syndrome type 3. The disease may be caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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== Function ==
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[[Category: Sasagawa, A.]]
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[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).<ref>PMID:26072516</ref> <ref>PMID:29235198</ref>
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[[Category: Tomizawa, T.]]
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== Evolutionary Conservation ==
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[[Category: Yokoyama, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: hisrs]]
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Check<jmol>
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[[Category: national project on protein structural and functional analyses]]
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<jmolCheckbox>
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[[Category: nppsfa]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x59_consurf.spt"</scriptWhenChecked>
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[[Category: riken structural genomics/proteomics initiative]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: rsgi]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: structural genomics]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x59 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:59:30 2007''
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Nameki N]]
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[[Category: Sasagawa A]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama S]]

Current revision

Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase

PDB ID 1x59

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