2djs

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[[Image:2djs.gif|left|200px]]
 
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{{Structure
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==Solution structures of the fn3 domain of human ephrin type-B receptor 1==
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|PDB= 2djs |SIZE=350|CAPTION= <scene name='initialview01'>2djs</scene>
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<StructureSection load='2djs' size='340' side='right'caption='[[2djs]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2djs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DJS FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= EPHB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2djs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2djs OCA], [https://pdbe.org/2djs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2djs RCSB], [https://www.ebi.ac.uk/pdbsum/2djs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2djs ProSAT], [https://www.topsan.org/Proteins/RSGI/2djs TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2djs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2djs OCA], [http://www.ebi.ac.uk/pdbsum/2djs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2djs RCSB]</span>
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[https://www.uniprot.org/uniprot/EPHB1_HUMAN EPHB1_HUMAN] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.<ref>PMID:9430661</ref> <ref>PMID:9499402</ref> <ref>PMID:12223469</ref> <ref>PMID:12925710</ref> <ref>PMID:18034775</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/2djs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2djs ConSurf].
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<div style="clear:both"></div>
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'''Solution structures of the fn3 domain of human ephrin type-B receptor 1'''
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==See Also==
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2DJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DJS OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Inoue M]]
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[[Category: Inoue, M.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S.]]
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[[Category: Sato M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Sato, M.]]
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[[Category: Yokoyama S]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama, S.]]
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[[Category: elk]]
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[[Category: hek6]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: net]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: tyrosine-protein kinase receptor eph-2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:35:31 2008''
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Current revision

Solution structures of the fn3 domain of human ephrin type-B receptor 1

PDB ID 2djs

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