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2dk9

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[[Image:2dk9.gif|left|200px]]
 
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==Solution structure of Calponin Homology domain of Human MICAL-1==
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The line below this paragraph, containing "STRUCTURE_2dk9", creates the "Structure Box" on the page.
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<StructureSection load='2dk9' size='340' side='right'caption='[[2dk9]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dk9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DK9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dk9 OCA], [https://pdbe.org/2dk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dk9 RCSB], [https://www.ebi.ac.uk/pdbsum/2dk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dk9 ProSAT]</span></td></tr>
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{{STRUCTURE_2dk9| PDB=2dk9 | SCENE= }}
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</table>
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== Function ==
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'''Solution structure of Calponin Homology domain of Human MICAL-1'''
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[https://www.uniprot.org/uniprot/MICA1_HUMAN MICA1_HUMAN] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.<ref>PMID:18305261</ref> <ref>PMID:21864500</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2DK9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DK9 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dk9_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Solution structure of calponin homology domain of Human MICAL-1., Sun H, Dai H, Zhang J, Jin X, Xiong S, Xu J, Wu J, Shi Y, J Biomol NMR. 2006 Dec;36(4):295-300. Epub 2006 Oct 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17043746 17043746]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dk9 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dai, H.]]
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[[Category: Dai H]]
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[[Category: Shi, Y.]]
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[[Category: Shi Y]]
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[[Category: Sun, H.]]
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[[Category: Sun H]]
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[[Category: Wu, J.]]
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[[Category: Wu J]]
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[[Category: Xiong, S.]]
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[[Category: Xiong S]]
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[[Category: Zhang, J.]]
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[[Category: Zhang J]]
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[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:36:16 2008''
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Current revision

Solution structure of Calponin Homology domain of Human MICAL-1

PDB ID 2dk9

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