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2dkx

From Proteopedia

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[[Image:2dkx.gif|left|200px]]
 
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{{Structure
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==Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)==
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|PDB= 2dkx |SIZE=350|CAPTION= <scene name='initialview01'>2dkx</scene>
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<StructureSection load='2dkx' size='340' side='right'caption='[[2dkx]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2dkx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= SPDEF, PDEF, PSE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dkx OCA], [https://pdbe.org/2dkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dkx RCSB], [https://www.ebi.ac.uk/pdbsum/2dkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dkx ProSAT], [https://www.topsan.org/Proteins/RSGI/2dkx TOPSAN]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)'''
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[https://www.uniprot.org/uniprot/SPDEF_HUMAN SPDEF_HUMAN] May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.<ref>PMID:10625666</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Disease==
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Check<jmol>
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Known diseases associated with this structure: Alzheimer disease, type 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Alzheimer disease, type 3, with spastic paraparesis and apraxia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Alzheimer disease, type 3, with spastic paraparesis and unusual plaques OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Cardiomyopathy, dilated, 1U OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Dementia, frontotemporal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Pick disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dkx_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2DKX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKX OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dkx ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Goroncy, A K.]]
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[[Category: Goroncy AK]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sato M]]
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[[Category: Sato, M.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: cell-free protein synthesis]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: protein regulation]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:28:23 2008''
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Current revision

Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)

PDB ID 2dkx

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