This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2dml

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:44, 29 May 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2dml.gif|left|200px]]
 
-
{{Structure
+
==The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6==
-
|PDB= 2dml |SIZE=350|CAPTION= <scene name='initialview01'>2dml</scene>
+
<StructureSection load='2dml' size='340' side='right'caption='[[2dml]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2dml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DML FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= Pdia6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dml OCA], [https://pdbe.org/2dml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dml RCSB], [https://www.ebi.ac.uk/pdbsum/2dml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dml ProSAT], [https://www.topsan.org/Proteins/RSGI/2dml TOPSAN]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dml OCA], [http://www.ebi.ac.uk/pdbsum/2dml PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dml RCSB]</span>
+
[https://www.uniprot.org/uniprot/PDIA6_MOUSE PDIA6_MOUSE] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity).
-
}}
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
'''The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6'''
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/2dml_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
2DML is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DML OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dml ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Protein disulfide-isomerase]]
+
[[Category: Inoue M]]
-
[[Category: Single protein]]
+
[[Category: Kigawa T]]
-
[[Category: Inoue, M.]]
+
[[Category: Koshiba S]]
-
[[Category: Kigawa, T.]]
+
[[Category: Tochio N]]
-
[[Category: Koshiba, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
-
[[Category: Tochio, N.]]
+
-
[[Category: Yokoyama, S.]]
+
-
[[Category: endoplasmic reticulum]]
+
-
[[Category: isomerase]]
+
-
[[Category: national project on protein structural and functional analyse]]
+
-
[[Category: nppsfa]]
+
-
[[Category: redox-active center]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: structural genomic]]
+
-
[[Category: thioredoxin domain-containing protein 7]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:36:39 2008''
+

Current revision

The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6

PDB ID 2dml

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dml"
Personal tools