2dmo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:44, 29 May 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2dmo.gif|left|200px]]
 
-
{{Structure
+
==Refined solution structure of the 1st SH3 domain from human Neutrophil cytosol factor 2 (NCF-2)==
-
|PDB= 2dmo |SIZE=350|CAPTION= <scene name='initialview01'>2dmo</scene>
+
<StructureSection load='2dmo' size='340' side='right'caption='[[2dmo]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2dmo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1x3v 1x3v]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DMO FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= NCF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dmo OCA], [https://pdbe.org/2dmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dmo RCSB], [https://www.ebi.ac.uk/pdbsum/2dmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dmo ProSAT], [https://www.topsan.org/Proteins/RSGI/2dmo TOPSAN]</span></td></tr>
-
}}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/NCF2_HUMAN NCF2_HUMAN] Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2) [MIM:[https://omim.org/entry/233710 233710]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:8286749</ref> <ref>PMID:9070911</ref> <ref>PMID:10498624</ref> <ref>PMID:10598813</ref> <ref>PMID:11112388</ref> <ref>PMID:16937026</ref> <ref>PMID:18625437</ref> <ref>PMID:19624736</ref> <ref>PMID:20167518</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NCF2_HUMAN NCF2_HUMAN] NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/2dmo_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dmo ConSurf].
 +
<div style="clear:both"></div>
-
'''Refined solution structure of the 1st SH3 domain from human Neutrophil cytosol factor 2 (NCF-2)'''
+
==See Also==
-
 
+
*[[NADPH oxidase 3D structures|NADPH oxidase 3D structures]]
-
 
+
== References ==
-
==Disease==
+
<references/>
-
Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608515 608515]]
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2DMO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1X3V. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMO OCA].
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Chikayama, E.]]
+
[[Category: Chikayama E]]
-
[[Category: Inoue, M.]]
+
[[Category: Inoue M]]
-
[[Category: Kigawa, T.]]
+
[[Category: Kigawa T]]
-
[[Category: Koshiba, S.]]
+
[[Category: Koshiba S]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Tochio N]]
-
[[Category: Tochio, N.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: national project on protein structural and functional analyse]]
+
-
[[Category: neutrophil cytosol factor]]
+
-
[[Category: nppsfa]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: sh3 domain]]
+
-
[[Category: structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:29:03 2008''
+

Current revision

Refined solution structure of the 1st SH3 domain from human Neutrophil cytosol factor 2 (NCF-2)

PDB ID 2dmo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dmo"
Personal tools