This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2e9h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2e9h" size="350" color="white" frame="true" align="right" spinBox="true" caption="2e9h" /> '''Solution structure of the eIF-5_eIF-2B domai...)
Current revision (18:48, 29 May 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2e9h.jpg|left|200px]]<br /><applet load="2e9h" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2e9h" />
 
-
'''Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5'''<br />
 
-
==About this Structure==
+
==Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5==
-
2E9H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9H OCA].
+
<StructureSection load='2e9h' size='340' side='right'caption='[[2e9h]]' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2e9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E9H FirstGlance]. <br>
-
[[Category: Harada, T.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
[[Category: Kigawa, T.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Koshiba, S.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e9h OCA], [https://pdbe.org/2e9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e9h RCSB], [https://www.ebi.ac.uk/pdbsum/2e9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e9h ProSAT], [https://www.topsan.org/Proteins/RSGI/2e9h TOPSAN]</span></td></tr>
-
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+
</table>
-
[[Category: Tochio, N.]]
+
== Function ==
-
[[Category: Tomizawa, T.]]
+
[https://www.uniprot.org/uniprot/IF5_HUMAN IF5_HUMAN] Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
-
[[Category: Watanabe, S.]]
+
== Evolutionary Conservation ==
-
[[Category: Yokoyama, S.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: ZN]]
+
Check<jmol>
-
[[Category: c4 type zinc finger]]
+
<jmolCheckbox>
-
[[Category: national project on protein structural and functional analyses]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e9h_consurf.spt"</scriptWhenChecked>
-
[[Category: nppsfa]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: riken structural genomics/proteomics initiative]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: rsgi]]
+
</jmolCheckbox>
-
[[Category: structural genomics]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e9h ConSurf].
-
[[Category: translation initiation factor]]
+
<div style="clear:both"></div>
-
[[Category: zinc binding]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:05:21 2008''
+
==See Also==
 +
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Harada T]]
 +
[[Category: Kigawa T]]
 +
[[Category: Koshiba S]]
 +
[[Category: Tochio N]]
 +
[[Category: Tomizawa T]]
 +
[[Category: Watanabe S]]
 +
[[Category: Yokoyama S]]

Current revision

Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5

PDB ID 2e9h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2e9h"
Personal tools