This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2e9h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2e9h" [edit=sysop:move=sysop])
Current revision (18:48, 29 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2e9h.png|left|200px]]
 
-
{{STRUCTURE_2e9h| PDB=2e9h | SCENE= }}
+
==Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5==
-
 
+
<StructureSection load='2e9h' size='340' side='right'caption='[[2e9h]]' scene=''>
-
===Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2e9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E9H FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[2e9h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9H OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e9h OCA], [https://pdbe.org/2e9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e9h RCSB], [https://www.ebi.ac.uk/pdbsum/2e9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e9h ProSAT], [https://www.topsan.org/Proteins/RSGI/2e9h TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IF5_HUMAN IF5_HUMAN] Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e9h_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e9h ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
+
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Harada, T.]]
+
[[Category: Large Structures]]
-
[[Category: Kigawa, T.]]
+
[[Category: Harada T]]
-
[[Category: Koshiba, S.]]
+
[[Category: Kigawa T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Koshiba S]]
-
[[Category: Tochio, N.]]
+
[[Category: Tochio N]]
-
[[Category: Tomizawa, T.]]
+
[[Category: Tomizawa T]]
-
[[Category: Watanabe, S.]]
+
[[Category: Watanabe S]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: C4 type zinc finger]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Translation]]
+
-
[[Category: Translation initiation factor]]
+
-
[[Category: Zinc binding]]
+

Current revision

Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5

PDB ID 2e9h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2e9h"
Personal tools