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2ebl

From Proteopedia

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[[Image:2ebl.jpg|left|200px]]
 
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{{Structure
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==Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1==
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|PDB= 2ebl |SIZE=350|CAPTION= <scene name='initialview01'>2ebl</scene>
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<StructureSection load='2ebl' size='340' side='right'caption='[[2ebl]]' scene=''>
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+191'>AC1</scene> and <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+241'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2ebl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBL FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= NR2F1, EAR3, ERBAL3, TFCOUP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebl OCA], [https://pdbe.org/2ebl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebl RCSB], [https://www.ebi.ac.uk/pdbsum/2ebl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebl ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebl TOPSAN]</span></td></tr>
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</table>
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'''Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1'''
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== Function ==
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[https://www.uniprot.org/uniprot/COT1_HUMAN COT1_HUMAN] Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.<ref>PMID:10644740</ref> <ref>PMID:11682620</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2EBL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBL OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2ebl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebl ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Harada, T.]]
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[[Category: Harada T]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Watabe S]]
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[[Category: Watabe, S.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoneyama M]]
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[[Category: Yoneyama, M.]]
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[[Category: ZN]]
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[[Category: dna-binding]]
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[[Category: ear3]]
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[[Category: erbal3]]
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[[Category: metal-binding]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: nuclear protein]]
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[[Category: receptor]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: tfcoup1]]
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[[Category: transcription]]
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[[Category: transcription regulation]]
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[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:37:54 2008''
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Current revision

Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1

PDB ID 2ebl

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