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2ecm
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2ecm" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ecm" /> '''Solution structure of the RING domain of the...) |
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| - | [[Image:2ecm.jpg|left|200px]]<br /><applet load="2ecm" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2ecm" /> | ||
| - | '''Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus'''<br /> | ||
| - | == | + | ==Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus== |
| - | + | <StructureSection load='2ecm' size='340' side='right'caption='[[2ecm]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2ecm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecm OCA], [https://pdbe.org/2ecm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecm RCSB], [https://www.ebi.ac.uk/pdbsum/2ecm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecm ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecm TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZN363_MOUSE ZN363_MOUSE] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecm_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecm ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Harada T]] | |
| - | [[Category: Harada | + | [[Category: Kigawa T]] |
| - | [[Category: Kigawa | + | [[Category: Koshiba S]] |
| - | [[Category: Koshiba | + | [[Category: Miyamoto K]] |
| - | [[Category: Miyamoto | + | [[Category: Watanabe S]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Watanabe | + | [[Category: Yoneyama M]] |
| - | [[Category: Yokoyama | + | |
| - | [[Category: Yoneyama | + | |
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Current revision
Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus
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Categories: Large Structures | Mus musculus | Harada T | Kigawa T | Koshiba S | Miyamoto K | Watanabe S | Yokoyama S | Yoneyama M
