2eeh

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{{Seed}}
 
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[[Image:2eeh.png|left|200px]]
 
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==Solution Structure of First PDZ domain of PDZ Domain Containing Protein 7==
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The line below this paragraph, containing "STRUCTURE_2eeh", creates the "Structure Box" on the page.
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<StructureSection load='2eeh' size='340' side='right'caption='[[2eeh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2eeh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EEH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eeh OCA], [https://pdbe.org/2eeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eeh RCSB], [https://www.ebi.ac.uk/pdbsum/2eeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eeh ProSAT], [https://www.topsan.org/Proteins/RSGI/2eeh TOPSAN]</span></td></tr>
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{{STRUCTURE_2eeh| PDB=2eeh | SCENE= }}
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</table>
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== Disease ==
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===Solution Structure of First PDZ domain of PDZ Domain Containing Protein 7===
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[https://www.uniprot.org/uniprot/PDZD7_HUMAN PDZD7_HUMAN] Usher syndrome type 2. A chromosomal aberration disrupting PDZD7 has been found in patients with non-syndromic sensorineural deafness. Translocation t(10;11),t(10;11). The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. PDZD7 mutations have been found in combination with mutations in USH2A and GPR98 in patients affected by Usher syndrome, suggesting a role as contributor to digenic Usher syndrome or a modifier of retinal disease expression.
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== Function ==
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[https://www.uniprot.org/uniprot/PDZD7_HUMAN PDZD7_HUMAN]
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==About this Structure==
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== Evolutionary Conservation ==
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2EEH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EEH OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/2eeh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eeh ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, K.]]
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[[Category: Kigawa T]]
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[[Category: Niraula, T N.]]
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[[Category: Koshiba K]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Niraula TN]]
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[[Category: Tochio, N.]]
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[[Category: Tochio N]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Metal binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Pdz domain]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 16:12:13 2008''
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Current revision

Solution Structure of First PDZ domain of PDZ Domain Containing Protein 7

PDB ID 2eeh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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