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2eme

From Proteopedia

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[[Image:2eme.png|left|200px]]
 
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{{STRUCTURE_2eme| PDB=2eme | SCENE= }}
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==Solution structure of the C2H2 type zinc finger (region 725-757) of human Zinc finger protein 473==
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<StructureSection load='2eme' size='340' side='right'caption='[[2eme]]' scene=''>
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===Solution structure of the C2H2 type zinc finger (region 725-757) of human Zinc finger protein 473===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2eme]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EME FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[2eme]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EME OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eme OCA], [https://pdbe.org/2eme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eme RCSB], [https://www.ebi.ac.uk/pdbsum/2eme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eme ProSAT], [https://www.topsan.org/Proteins/RSGI/2eme TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/2eme_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eme ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Abe, H.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Abe H]]
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[[Category: Kobayashi, N.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Kobayashi N]]
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[[Category: Li, H.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Li H]]
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[[Category: Saito, K.]]
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[[Category: Saito K]]
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[[Category: Sato, M.]]
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[[Category: Sato M]]
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[[Category: Tochio, N.]]
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[[Category: Tochio N]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Zf-c2h2]]
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Current revision

Solution structure of the C2H2 type zinc finger (region 725-757) of human Zinc finger protein 473

PDB ID 2eme

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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