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2eo6

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==Solution structure of the SH2 domain from mouse B-cell linker protein BLNK==
==Solution structure of the SH2 domain from mouse B-cell linker protein BLNK==
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<StructureSection load='2eo6' size='340' side='right' caption='[[2eo6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2eo6' size='340' side='right'caption='[[2eo6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EO6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EO6 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Blnk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [http://pdbe.org/2eo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [http://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [https://pdbe.org/2eo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [https://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eo6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BLNK_MOUSE BLNK_MOUSE]] Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.<ref>PMID:9705962</ref> <ref>PMID:12761551</ref> <ref>PMID:18369315</ref>
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[https://www.uniprot.org/uniprot/BLNK_MOUSE BLNK_MOUSE] Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.<ref>PMID:9705962</ref> <ref>PMID:12761551</ref> <ref>PMID:18369315</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eo6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eo6_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eo6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Hayashi, F]]
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[[Category: Mus musculus]]
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[[Category: Kurosaki, C]]
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[[Category: Hayashi F]]
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[[Category: Structural genomic]]
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[[Category: Kurosaki C]]
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[[Category: Sano, R]]
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[[Category: Sano R]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Yoshida, M]]
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[[Category: Yoshida M]]
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[[Category: B-cell adapter containing sh2 domain protein]]
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[[Category: B-cell adapter containing src homology 2 domain protein]]
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[[Category: Cytoplasmic adapter protein]]
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[[Category: Lymphocyte antigen 57]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sh2]]
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[[Category: Signaling protein]]
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[[Category: Slp-65]]
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[[Category: Src homology 2 domain-containing leukocyte protein of 65 kda]]
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Current revision

Solution structure of the SH2 domain from mouse B-cell linker protein BLNK

PDB ID 2eo6

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