This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2eod

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px {{Structure |PDB= 2eod |SIZE=350|CAPTION= <scene name='initialview01'>2eod</scene> |SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+300'>AC1</s...)
Current revision (18:53, 29 May 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2eod.jpg|left|200px]]
 
-
{{Structure
+
==Solution structure of TRAF-type zinc finger domains (190- 248) from human TNF receptor-associated factor 4==
-
|PDB= 2eod |SIZE=350|CAPTION= <scene name='initialview01'>2eod</scene>
+
<StructureSection load='2eod' size='340' side='right'caption='[[2eod]]' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+300'>AC1</scene> and <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+400'>AC2</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[2eod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOD FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= TRAF4, CART1, MLN62, RNF83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02176 zf-TRAF]</span>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eod OCA], [https://pdbe.org/2eod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eod RCSB], [https://www.ebi.ac.uk/pdbsum/2eod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eod ProSAT], [https://www.topsan.org/Proteins/RSGI/2eod TOPSAN]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eod OCA], [http://www.ebi.ac.uk/pdbsum/2eod PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eod RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eod_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eod ConSurf].
 +
<div style="clear:both"></div>
-
'''Solution structure of TRAF-type zinc finger domains (190- 248) from human TNF receptor-associated factor 4'''
+
==See Also==
-
 
+
*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2EOD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOD OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hayashi, F.]]
+
[[Category: Hayashi F]]
-
[[Category: Nagashima, T.]]
+
[[Category: Nagashima T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: national project on protein structural and functional analyse]]
+
-
[[Category: nf-kb]]
+
-
[[Category: nppsfa]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: signaling protein]]
+
-
[[Category: structural genomic]]
+
-
[[Category: tnf]]
+
-
[[Category: tnfr]]
+
-
[[Category: zinc binding]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:56:59 2008''
+

Current revision

Solution structure of TRAF-type zinc finger domains (190- 248) from human TNF receptor-associated factor 4

PDB ID 2eod

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2eod"
Personal tools