2fho

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[[Image:2fho.jpg|left|200px]]
 
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{{Structure
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==NMR solution structure of the human spliceosomal protein complex p14-SF3b155==
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|PDB= 2fho |SIZE=350|CAPTION= <scene name='initialview01'>2fho</scene>
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<StructureSection load='2fho' size='340' side='right'caption='[[2fho]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2fho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FHO FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= SF3b155 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), p14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fho OCA], [https://pdbe.org/2fho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fho RCSB], [https://www.ebi.ac.uk/pdbsum/2fho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fho ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fho OCA], [http://www.ebi.ac.uk/pdbsum/2fho PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fho RCSB]</span>
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[https://www.uniprot.org/uniprot/SF3B1_HUMAN SF3B1_HUMAN] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fho_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fho ConSurf].
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<div style="clear:both"></div>
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'''NMR solution structure of the human spliceosomal protein complex p14-SF3b155'''
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==See Also==
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*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
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__TOC__
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==Disease==
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</StructureSection>
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Known disease associated with this structure: Immunodeficiency due to defect in MAPBP-interacting protein OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610389 610389]]
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==About this Structure==
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2FHO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHO OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Dohmae, N.]]
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[[Category: Dohmae N]]
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[[Category: Guntert, P.]]
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[[Category: Guntert P]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kuwasako, K.]]
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[[Category: Kuwasako K]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Seraphin B]]
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[[Category: Seraphin, B.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rrm domain]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:02:55 2008''
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Current revision

NMR solution structure of the human spliceosomal protein complex p14-SF3b155

PDB ID 2fho

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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