2fho
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2fho" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fho" /> '''NMR solution structure of the human spliceo...) |
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| - | [[Image:2fho.gif|left|200px]]<br /> | ||
| - | <applet load="2fho" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2fho" /> | ||
| - | '''NMR solution structure of the human spliceosomal protein complex p14-SF3b155'''<br /> | ||
| - | == | + | ==NMR solution structure of the human spliceosomal protein complex p14-SF3b155== |
| - | + | <StructureSection load='2fho' size='340' side='right'caption='[[2fho]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2fho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FHO FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fho OCA], [https://pdbe.org/2fho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fho RCSB], [https://www.ebi.ac.uk/pdbsum/2fho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fho ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/SF3B1_HUMAN SF3B1_HUMAN] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. | |
| - | [ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | [[ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fho_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fho ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | + | ==See Also== | |
| + | *[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dohmae N]] | ||
| + | [[Category: Guntert P]] | ||
| + | [[Category: Inoue M]] | ||
| + | [[Category: Kuwasako K]] | ||
| + | [[Category: Muto Y]] | ||
| + | [[Category: Seraphin B]] | ||
| + | [[Category: Shirouzu M]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
NMR solution structure of the human spliceosomal protein complex p14-SF3b155
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Categories: Homo sapiens | Large Structures | Dohmae N | Guntert P | Inoue M | Kuwasako K | Muto Y | Seraphin B | Shirouzu M | Yokoyama S
