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2g2b
From Proteopedia
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| - | [[Image:2g2b.gif|left|200px]]<br /><applet load="2g2b" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2g2b" /> | ||
| - | '''NMR structure of the human allograft inflammatory factor 1'''<br /> | ||
| - | == | + | ==NMR structure of the human allograft inflammatory factor 1== |
| - | + | <StructureSection load='2g2b' size='340' side='right'caption='[[2g2b]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2g2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2B FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2b OCA], [https://pdbe.org/2g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2b RCSB], [https://www.ebi.ac.uk/pdbsum/2g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2b ProSAT], [https://www.topsan.org/Proteins/CESG/2g2b TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AIF1_HUMAN AIF1_HUMAN] Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.<ref>PMID:15117732</ref> <ref>PMID:16049345</ref> <ref>PMID:18699778</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/2g2b_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g2b ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Markley JL]] | |
| - | [[Category: Markley | + | [[Category: Newman CL]] |
| - | [[Category: Newman | + | [[Category: Song J]] |
| - | [[Category: Song | + | [[Category: Tyler RC]] |
| - | [[Category: Tyler | + | [[Category: Vinarov D]] |
| - | [[Category: Vinarov | + | |
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Current revision
NMR structure of the human allograft inflammatory factor 1
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Categories: Homo sapiens | Large Structures | Markley JL | Newman CL | Song J | Tyler RC | Vinarov D
