2g7h

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{{Seed}}
 
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[[Image:2g7h.png|left|200px]]
 
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==Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)==
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The line below this paragraph, containing "STRUCTURE_2g7h", creates the "Structure Box" on the page.
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<StructureSection load='2g7h' size='340' side='right'caption='[[2g7h]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G7H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7h OCA], [https://pdbe.org/2g7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g7h RCSB], [https://www.ebi.ac.uk/pdbsum/2g7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7h ProSAT]</span></td></tr>
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{{STRUCTURE_2g7h| PDB=2g7h | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OGT_METJA OGT_METJA] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.<ref>PMID:16826543</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g7h ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the thermophile Methanococcus jannaschii has been determined using multinuclear multidimensional NMR spectroscopy. The structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain. The C-terminal domain is more highly conserved in both sequence and structure. Regions of the protein show broadening, reflecting conformational flexibility that is likely related to function.
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===Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)===
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Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase.,Roberts A, Pelton JG, Wemmer DE Magn Reson Chem. 2006 Jul;44 Spec No:S71-82. PMID:16826543<ref>PMID:16826543</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2g7h" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16826543}}, adds the Publication Abstract to the page
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16826543 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16826543}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2G7H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7H OCA].
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==Reference==
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<ref group="xtra">PMID:16826543</ref><references group="xtra"/>
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Roberts, A.]]
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[[Category: Roberts A]]
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[[Category: Dna methyltransferase]]
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[[Category: Dna repair]]
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[[Category: Nmr]]
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[[Category: Protein structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:05:08 2009''
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Current revision

Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)

PDB ID 2g7h

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