2gsb

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{{Seed}}
 
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[[Image:2gsb.png|left|200px]]
 
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==Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1==
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The line below this paragraph, containing "STRUCTURE_2gsb", creates the "Structure Box" on the page.
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<StructureSection load='2gsb' size='340' side='right'caption='[[2gsb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsb OCA], [https://pdbe.org/2gsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gsb RCSB], [https://www.ebi.ac.uk/pdbsum/2gsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gsb ProSAT], [https://www.topsan.org/Proteins/RSGI/2gsb TOPSAN]</span></td></tr>
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{{STRUCTURE_2gsb| PDB=2gsb | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RASA1_HUMAN RASA1_HUMAN] Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas. Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation (CMAVM) [MIM:[https://omim.org/entry/608354 608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.<ref>PMID:14639529</ref> Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:[https://omim.org/entry/608355 608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
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== Function ==
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[https://www.uniprot.org/uniprot/RASA1_HUMAN RASA1_HUMAN] Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.<ref>PMID:8360177</ref> <ref>PMID:11389730</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gsb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gsb ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1===
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==See Also==
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*[[Ras GTPase activating protein|Ras GTPase activating protein]]
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== References ==
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==About this Structure==
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<references/>
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2GSB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSB OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: Kurosaki, C.]]
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[[Category: Kurosaki C]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Suetake T]]
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[[Category: Suetake, T.]]
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[[Category: Yokoyma S]]
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[[Category: Yokoyma, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: Gap]]
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[[Category: Gtpase-activating protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: P120gap]]
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[[Category: Ras p21 protein activator]]
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[[Category: Rasgap]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 29 07:07:24 2008''
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Current revision

Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1

PDB ID 2gsb

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OCA

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