2jv5

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{{Seed}}
 
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[[Image:2jv5.jpg|left|200px]]
 
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<!--
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==Nogo54==
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The line below this paragraph, containing "STRUCTURE_2jv5", creates the "Structure Box" on the page.
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<StructureSection load='2jv5' size='340' side='right'caption='[[2jv5]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jv5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JV5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jv5 OCA], [https://pdbe.org/2jv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jv5 RCSB], [https://www.ebi.ac.uk/pdbsum/2jv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jv5 ProSAT]</span></td></tr>
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{{STRUCTURE_2jv5| PDB=2jv5 | SCENE= }}
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</table>
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== Function ==
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===Nogo54===
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[https://www.uniprot.org/uniprot/RTN4_HUMAN RTN4_HUMAN] Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.<ref>PMID:10667797</ref> <ref>PMID:11201742</ref> <ref>PMID:16965550</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2JV5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV5 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/2jv5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jv5 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Li, M.]]
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[[Category: Li M]]
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[[Category: Song, J.]]
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[[Category: Song J]]
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[[Category: Alternative splicing]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Membrane]]
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[[Category: Nogo54]]
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[[Category: Phosphorylation]]
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[[Category: Protein binding]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 14:04:59 2008''
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Current revision

Nogo54

PDB ID 2jv5

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