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2jx1

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==Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA==
==Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA==
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<StructureSection load='2jx1' size='340' side='right' caption='[[2jx1]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2jx1' size='340' side='right'caption='[[2jx1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jx1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jx1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX1 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx1 OCA], [http://pdbe.org/2jx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx1 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx1 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx1 OCA], [https://pdbe.org/2jx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MYT1_MOUSE MYT1_MOUSE]] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).<ref>PMID:9373037</ref>
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[https://www.uniprot.org/uniprot/MYT1_MOUSE MYT1_MOUSE] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).<ref>PMID:9373037</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx1_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx1_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Gamsjaeger, R]]
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[[Category: Mus musculus]]
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[[Category: Kobus, F J]]
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[[Category: Gamsjaeger R]]
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[[Category: Kwan, A H]]
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[[Category: Kobus FJ]]
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[[Category: Lehtomaki, E]]
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[[Category: Kwan AH]]
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[[Category: Lowry, J A]]
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[[Category: Lehtomaki E]]
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[[Category: Mackay, J P]]
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[[Category: Lowry JA]]
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[[Category: Matthews, J M]]
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[[Category: Mackay JP]]
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[[Category: Swanton, M K]]
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[[Category: Matthews JM]]
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[[Category: Protein-dna complex]]
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[[Category: Swanton MK]]
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[[Category: Transcription-dna complex]]
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Current revision

Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA

PDB ID 2jx1

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