2k20
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2k20 is ON HOLD until Paper Publication Authors: Feng, W., Wu, H., Chan, L., Zhang, M. Description: Solution structure of Par-3 PDZ3 in complex wit...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of Par-3 PDZ3 in complex with PTEN peptide== | |
| - | + | <StructureSection load='2k20' size='340' side='right'caption='[[2k20]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2k20]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K20 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k20 OCA], [https://pdbe.org/2k20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k20 RCSB], [https://www.ebi.ac.uk/pdbsum/2k20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k20 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| + | [https://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k20_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k20 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Chan L]] | ||
| + | [[Category: Feng W]] | ||
| + | [[Category: Wu H]] | ||
| + | [[Category: Zhang M]] | ||
Current revision
Solution structure of Par-3 PDZ3 in complex with PTEN peptide
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Categories: Large Structures | Rattus norvegicus | Chan L | Feng W | Wu H | Zhang M
